Articolul precedent |
Articolul urmator |
328 0 |
SM ISO690:2012 GROPPA, Stanislav, CIOLAC, Dumitru, DUARTE, Carolina , GARCIA, Christopher, GASNAȘ (CATERENIUC), Daniela, LEAHU, Pavel, EFREMOVA, Daniela, GASNAŞ, Alexandru, BĂLĂNUȚĂ, Tatiana, MÎRZAC, Daniela, MOVILĂ, Alexandru. Molecular Mechanisms of SARS-CoV-2/COVID-19 Pathogenicity on the Central Nervous System: Bridging Experimental Probes to Clinical Evidence and Therapeutic Interventions. In: Advances in Experimental Medicine and Biology, 1 iunie 2022, Berlin. Berlin, Germania: Springer, 2022, Vol.1376, pp. 1-27. ISSN 00652598. DOI: https://doi.org/10.1007/5584_2021_675 |
EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
Advances in Experimental Medicine and Biology Vol.1376, 2022 |
||||||
Sesiunea "Advances in Experimental Medicine and Biology" Berlin, Germania, 1 iunie 2022 | ||||||
|
||||||
DOI:https://doi.org/10.1007/5584_2021_675 | ||||||
Pag. 1-27 | ||||||
|
||||||
Vezi articolul | ||||||
Rezumat | ||||||
The coronavirus disease 2019 (COVID-19) pandemic, induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has dramatically impacted the global healthcare systems, constantly challenging both research and clinical practice. Although it was initially believed that the SARS-CoV-2 infection is limited merely to the respiratory system, emerging evidence indicates that COVID-19 affects multiple other systems including the central nervous system (CNS). Furthermore, most of the published clinical studies indicate that the confirmed CNS inflammatory manifestations in COVID-19 patients are meningitis, encephalitis, acute necrotizing encephalopathy, acute transverse myelitis, and acute disseminated encephalomyelitis. In addition, the neuroinflammation along with accelerated neurosenescence and susceptible genetic signatures in COVID-19 patients might prime the CNS to neurodegeneration and precipitate the occurrence of neurodegenerative diseases, including Alzheimer’s and Parkinson’s diseases. Thus, this review provides a critical evaluation and interpretive analysis of existing published preclinical as well as clinical studies on the key molecular mechanisms modulating neuroinflammation and neurodegeneration induced by the SARS-CoV-2. In addition, the essential age- and gender-dependent impacts of SARS-CoV-2 on the CNS of COVID-19 patients are also discussed. |
||||||
Cuvinte-cheie COVID-19, Neurodegeneration, neuroinflammation, Neuroinvasion, Neurosenescence, SARS-CoV-2 |
||||||
|