The study is an analysis of the population mortality dynamics in the Northern Development Region (RDN) of the Republic of Moldova over the last ten years. Population mortality is one of the main parameters of the population's health, which is directly or indirectly reflected in the demographic process influencing the birth rate, natural increase, life expectancy, marriage, etc. As a demographic phenomenon, mortality is the sum of all deaths recorded in a given period for a given population. Following the analysis, the average value of the general mortality of the population in the RDN is 1288 cases per 100 thousand inhabitants. The highest mortality rate is attested in Donduseni district with 1675 deaths per 100,000 inhabitants, followed by Briceni district - 1496 cases / 100,000 inhabitants, Edineț district with 1437 cases / 100,000 inhabitants; and the lowest level is registered in Soroca district - 1255 cases/100,000 inhabitants and Sîngerei district with 1105 cases. Bălți municipality records the lowest values, for the evaluation period, with an average of 898 deaths per 100 thousand inhabitants, at the same time, being with approx. 12% higher compared to other municipalities in the country and about 14% compared to the values recorded in the territory of RD Chisinau. At the national level, the general mortality of the population is estimated at 1100 cases per 100,000 inhabitants; the total average on the municipalities of the Republic of Moldova is - 803 cases / 100,000 inhabitants; and on RD Chișinău municipality registers the lowest values for the estimated period and constitutes 786 cases / 100,000 inhabitants. We note that the mortality rate of the population in the RDN has higher values compared to the Central Development Region (RDC) and the Southern Development Region (RDS), as well as the value per republic. Compared to the general mortality of the population in the RDC and RDS, the value in the RDN is about 10% higher (RDC - 1153 cases / 100,000 inhabitants, RDS - 1135 cases / 100,000 inhabitants), and compared to the national value, it is approx. 17% higher.