Purpose. To study the effectiveness of ACE inhibitor Lisinopril on hemodynamic indices in patients with chronic obstructive pulmonary disease (COPD). Materials and methods. The study included 48 COPD patients, stage II, in order to determine the effect of Lisinopril on hemodynamic indices and cardiac rhythm disorders. Results. Lisinopril administration resulted in decreased number of angina attacks, reducing the consumption of Nitroglycerin pills, decreased dyspnea and palpitations. We found a decreased number of premature ventricular (by 90,8%) and atrial (by 78,8%) complexes, decreased IRVT RV from 126,7 ± 2,7 to 112,5 ± 2,2 ms; E/A - from 1,14 ± 0,01 to 1,05±0,01, mean PAP - from 37,4 ± 3,4 to 24,1 ± 3,1 mm Hg, TDD RA - from 36,2 ± 0,6 to 33,9 ± 0,3 mm. TDV decreased by 10,7% and TSV by 9,9%. Treatment with Lisinopril caused increase in LV EF- by 8,4%. Also it the respiratory functionimprouved: FVC increased by 41,6%, FEV1 - by 29,2%, FEV1/FVC – by 13,7% and PaO2, - by 25,5%. Conclusions. Inclusion of Lisinopril in the treatment of patients with COPD resulted in reducing the number of premature ventricular and atrial complexes and causes positive dynamics of systolic and diastolic function of the ventricles of the heart without adverse effects on lung function, leads to the modification of the right heart chambers geometric indices and indices of right ventricle diastolic function with decreasing of mean PAP.