Aim: presentation of initial experience in surgical management of primary duodenal gastrointestinal stromal tumors. Case Report: 1. A 55-year-old male was admitted with a tumor of the papilla of Vater. A pancreaticoduodenectomy was performed with an uneventful recovery. After 11 months of disease-free survival - repeatedly admitted. During laparotomy a right hemicolectomy was practiced. Positive staining for c-KIT(CD117) and CD34 in the primary and recurrent tumor were consistent with the diagnostic criteria for GIST. Adjuvant treatment with imatinib mesylate was started. Despite the complex treatment the patient died 5 months later. 2. A 42-year-old female presented at our department with a CT suspected tumor of the duodenum. A segmental resection of D2 of duodenum was performed. After 40 months of disease-free survival the patient was repeatedly admitted. Local excision of a tumor of the mesentery was performed. Identical immunohistochemical features of positive c-KIT(CD117) staining were determined for primary and recurrent tumors. The tumor was finally diagnosed as a GIST originating from the duodenum and adjuvant treatment was initiated. At 12 months after surgery and adjuvant therapy the patient is asymptomatic. 3. A 61-year-old female was admitted with a suspected tumor of the duodenum. Segmental resection was performed. Positive staining for c-KIT(CD117) led us to the diagnosis of GIST of duodenum. The patient is free of recurrence after 5 months of follow-up. Conclusions: GISTs of duodenum allow to perform oncologically adequate but limited resections. Complex therapy in the perioperative period is a promising improvement of surgical treatment of GISTs.