This paper talks about the problem of the occupational stress and its economic and social consequences on organizational performance. Considered the disease of the XXI century, occupational stress should be treated with special attention from both senior managers and human resources specialists. In this context, are show the causes that lead to stress in the workplace, but also its negative effects both at individual and organizational levels. Tolerating professional stress can have serious economic and social repercussions on organizational performance. Considering that prolonged stress can lead to the development of the burnout syndrome, we found it necessary to address this issue which, too, has direct implications for organizational performance.