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SM ISO690:2012 VESIOLII, Sorina, SCUTARI, Corina. Drug interactions and adverse reactions in HIV-positive patients. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 435. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Pag. 435-435 | ||||||
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Rezumat | ||||||
Background. The therapeutic regimen associates a complex antiretroviral treatment and other drugs in associated diseases that can generate a series of pharmacokinetic and pharmacodynamic interactions. Objective of the study. Study of drug interactions between preparations used in the ARV treatment offered in the Republic of Moldova and other groups of drugs. Material and Methods. A review of the literature and officially published data on the treatment of HIV patients in the Republic of Moldova was conducted. Results. Doses for efavirenz, dolutegravir should be adjusted when methadone is used as replacement therapy. When efavirenz is administered, hormonal contraceptives should be avoided and an antiarrhythmic agent should be used other than amodiaquine, and when dolutegravir is administered, polyvalent cationic products containing Mg, Al, Fe, and Zn should be administered for at least 2 hours. At the same time, following ARV treatment, the administration of medicinal preparations containing lovastatin, simvastatin, astemizole, terfenadine, simeprevir, ombitasvir, phenobarbital, carbamazepine by their replacement should be avoided. Conclusion. Pharmaceutical assistance in HIV/AIDS differs from pharmaceutical assistance in other diseases due to the permanent need to balance between the control of acute, chronic and HIV/AIDS to avoid virological failure. |
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Cuvinte-cheie HIV, AIDS, drug interactions, ARV, dolutegravir, HIV, SIDA, interacțiuni medicamentoase, ARV, dolutegravir |
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