Articolul precedent |
Articolul urmator |
249 0 |
SM ISO690:2012 EVTODIENCO, Vladilena, MORAR, Ana, CAZACU, Maria, UNCU, Livia. Application of X-ray diffraction in researching the compatibility of active substances with excipients. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 436. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Pag. 436-436 | ||||||
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Rezumat | ||||||
Background. Compatibility studies between active ingredients and excipients in a pharmaceutical form are a key step in the development of a new drug, being applied several methods to investigate potential transformations at the molecular level. Objective of the study. Evaluation of the possibilities of using X-ray diffraction in researching of the compatibility of active principles with excipients in pharmaceutical forms. Material and Methods. Advanced bibliographic study using the databases Medline, Environmental Issues & Policy Index, Environmental Sci & Pollution Mgmt, Scopus (Elsevier), Current Contents, Scirus. Over 120 bibliographic sources were evaluated. Results. An increasing number of studies have focused on the development of non-specific rapid methods for assessing compatibility at an early stage of the development process. In recent years, more and more studies attest to the use of X-ray diffraction techniques. In 88% of the evaluated sources, X-ray diffraction has been combined with spectral (FT-IR) and thermal (DSC) methods, being applied only for crystalline substances testing. At 24% of the evaluated articles, molecular interactions between active and auxiliary substances were reported. Some researchers (12% of sources) successfully apply Bragg's law in interpreting diffractograms. Conclusion. The identification of crystalline substances by X-ray diffraction with determining of the interplanar distance and the intensity of deviation from these X-ray planes is an advantageous method of detecting incompatibilities. |
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Cuvinte-cheie X-ray diffraction, compatibility, Difracţie cu raze X, compatibilitate |
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