Articolul precedent |
Articolul urmator |
329 2 |
Ultima descărcare din IBN: 2023-12-27 21:25 |
SM ISO690:2012 CĂLCÎI, Cornelia, SPRINCEAN, Mariana, FEGHIU, Ludmila, CUZNETZ, Ludmila, GROPPA, Stanislav, HADJIU, Svetlana. Transitory MRI changes after the vigabatrin treatment (clinical case). In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 382. ISBN 978-9975-82-223-7 (PDF).. |
EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
|
||||||
Pag. 382-382 | ||||||
|
||||||
Descarcă PDF | ||||||
Rezumat | ||||||
Background. Some studies show an association between the occurrence of neuroimaging changes (MRI) and Vigabatrin treatment in West syndrome in children, all changes being reversible and dose-dependent. Objective of the study. Evaluation of neuroimaging peculiarities secondary to Vigabatrin treatment based on a clinical case. Material and Methods. We evaluated the case of a 1-year-old 7-month-old child diagnosed with West syndrome who was hospitalized in 2019 in the IMSP mother and Child Institute, where he received treatment with Vigabatrin. The first neuroimaging investigation-MRI 3 Ts was performed at the age of 8 months, and the repeated one after 6 months of treatment with Vigabatrin. Results. At the age of 6 months the child presented the clinical picture of infantile spasms and delay in neuropsychic development, being diagnosed with West syndrome. The child performed the first brain MRI, where periventricular cysts, a minimized volume of cerebral white matter with periventricular gliosis, with reduction of hippocampal volume and enlargement of the ventricular and cisternal system were described. After the initiation of Vigabatrin treatment, the seizures stopped. The same changes were described on the repeated MRI examination (after 6 months), but small gliotic lesions appeared in the brainstem and tegmet, which were not previously described. Conclusion. Brain MRI changes may be seen in children with epilepsy treated with Vigabatrin. These may include increased signal in T2 and transient changes in the brainstem, usually being dose dependent and disappearing after discontinuation of treatment. |
||||||
Cuvinte-cheie West sindrom, epilepsy, Vigabatrin, sindromul West, epilepsie, Vigabatrin |
||||||
|
Google Scholar Export
<meta name="citation_title" content="Transitory MRI changes after the vigabatrin treatment (clinical case)"> <meta name="citation_author" content="Călcîi Cornelia"> <meta name="citation_author" content="Sprincean Mariana"> <meta name="citation_author" content="Feghiu Ludmila"> <meta name="citation_author" content="Cuznetz Ludmila"> <meta name="citation_author" content="Groppa Stanislav"> <meta name="citation_author" content="Hadjiu Svetlana"> <meta name="citation_publication_date" content="2021"> <meta name="citation_collection_title" content="Cercetarea în biomedicină și sănătate: calitate, excelență și performanță"> <meta name="citation_firstpage" content="382"> <meta name="citation_lastpage" content="382"> <meta name="citation_pdf_url" content="https://ibn.idsi.md/sites/default/files/imag_file/382.pdf">