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 SM ISO690:2012CERNAT, Mircea, MIŞIN, Igor, ANTOCI, Lilian, GODOROJA, Vitalie. Tumorile gastrointestinale stromale (gist) ale duodenului. In: Chirurgia (București, Romania), 2018, nr. S1(113), pp. 189-190. ISSN 1221-9118. |
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  Chirurgia (București, Romania) |
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| Numărul S1(113) / 2018 / ISSN 1221-9118 | ||||||
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Introducere: Tumorile gastrointestinale stromale (GIST) sunt cele mai frecvente tumori mezenchimale ale tractului gastro-intestinal. Introduction: gastrointestinal stromal tumors (GIST) are the most common mesenchimal tumors of the gastrointestinal tract. 5% |
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| Cuvinte-cheie GIST, duoden, tratament chirurgical, terapie țintã, GIST, duodenum, surgical treatment, target therapy |
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<?xml version='1.0' encoding='utf-8'?> <oai_dc:dc xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:oai_dc='http://www.openarchives.org/OAI/2.0/oai_dc/' xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' xsi:schemaLocation='http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd'> <dc:creator>Cernat, M.V.</dc:creator> <dc:creator>Mişin, I.V.</dc:creator> <dc:creator>Antoci, L.T.</dc:creator> <dc:creator>Godoroja, V.I.</dc:creator> <dc:date>2018-07-09</dc:date> <dc:description xml:lang='ro'><p>Introducere: Tumorile gastrointestinale stromale (GIST) sunt cele mai frecvente tumori mezenchimale ale tractului gastro-intestinal.<br />5% din GIST sunt localizate în duoden.<br />Obiectiv: Analiza frecvenåei, particularitãåilor tabloului clinic, aspectelor histopatologice æi imunohistochimice æi a rezultatelor tratamentului<br />tumorilor GIST duodenale.<br />Material æi metode: 6 pacienåi cu GIST (c-kit(CD117)(+) ale duodenului operaåi între 2007–2015.<br />Rezultate: Vârsta medie – 53.7±2.0ani. Raportul B:F=1:2. Simptomul principal – durerea abdominalã în 3(50%) cazuri, GIST depistat<br />ocazional – în 3(50%) cazuri. Prezentare iniåialã print-o complicaåie – hemoragie digestivã superiorã în 2(33.3%) cazuri. Localizarea<br />tumorilor în duoden: în D2 – 3(50%) pacienåi, D3 – 3(50%). Dimensiunea medie a tumorilor GIST duodenale – 7.6±1.9 cm. Tumorile<br />GIST cu dimensiuni ≤5cm vs. >5cm – 2(33.3%) vs. 4(66.7%) (p<0.05). Caracterul exoluminal de creætere al GIST – 2 (33.3%) vs.<br />caracter mixt de creætere – 4 (66.7%) (p<0.05). Frecvenåa tumorior GIST cu risc redus (≤5/50 HPF) – 2(33.3%) pacienåi, cu risc înalt<br />(>5/50 HPF) – 4(66.7%) (p<0.05). Numãrul mediu al mitozelor pentru grupul cu risc redus – 3.5±1.5, pentru grupul cu risc înalt –<br />10.5±2.9. Volumul operaåiilor: excizia tumorii duodenului – 2(33.3%) cazuri, rezecåia duodenului cu anastomozã – 2(33.3%), rezecåia<br />pancreatoduodenalã – 2(33.3%). Supravieåuirea generalã în medie – 41.3±10.9 luni. Metastaze la adresarea primarã s-au înregistrat<br />într-un caz (16.7%). Progresare a fost înregistratã într-un caz (16.7%). Au fost supuæi tratamentului combinat – chirurgical æi terapie<br />åintitã cu imatinib mesilat – 3(50%) pacienåi.<br />Concluzii: Tumorile GIST duodenale se pot prezenta printr-o complicaåie (hemoragie digestivã superiorã) sau sunt descoperite<br />incidental. GIST ale duodenului posedã mai frecvent un risc înalt de progresare sau metastazare. Tratamentul chirurgical rãmâne<br />metoda principalã de tratament.</p></dc:description> <dc:description xml:lang='en'><p>Introduction: gastrointestinal stromal tumors (GIST) are the most common mesenchimal tumors of the gastrointestinal tract. 5%<br />are localized in the duodenum.<br />Aim: analysis of frequency, clinical presentation, histopathological and immunohistochemical characteristics and treatment results<br />of duodenal GIST.<br />Material and methods: 6 patients with c-kit(CD117)(+) GIST of the duodenum treated between 2007–2015.<br />Results: mean age – 53.7±2.0 years. Male to female ratio – 1:2. Main symptom – abdominal pain in 3 cases (50%), incidental GISTs<br />– 3(50%). Initial presentation by a complication – upper gastrointestinal bleeding – in 2 cases (33.3%). Localization of tumors in<br />the duodenum: D2 – 3 cases (50%), D3 – 3(50%). Mean size of duodenal tumors – 7.6±1.9 cm. GIST with size ≤5cm vs. >5cm –<br />2(33.3%) vs. 4(66.7%) (p<0.05). Exoluminal growth – 2 cases (33.3%) vs. mixt growth – 4 (66.7%) (p<0.05). Frequency of GIST<br />with low risk (≤5/50 HPF) – 2(33.3%), with high risk (>5/50 HPF) – 4(66.7%) (p<0.05). Mean number of mitosis for the low risk<br />group – 3.5±1.5, for the high risk group – 10.5±2.9. Surgery: excision of duodenal tumor – in 2 (33.3%) cases, duodenal resection<br />with anastomosis – 2(33.3%), duodenopancreatectomy – 2(33.3%). Overall survival was 41.3±10.9 months. Metastatic disease at<br />admission was registered in one case. Progression – in one case (16.7%). Surgery followed by target treatment – in 3 patients<br />(50%).<br />Conclusions: duodenal GISTs can present at admission with a complication (upper gastrointestinal bleeding) or are incidental.<br />Duodenal GISTs have more frequently a high risk of progression and surgical treatment is still the main treatment.</p></dc:description> <dc:source>Chirurgia (București, Romania) 113 (S1) 189-190</dc:source> <dc:subject>GIST</dc:subject> <dc:subject>duoden</dc:subject> <dc:subject>tratament chirurgical</dc:subject> <dc:subject>terapie țintã</dc:subject> <dc:subject>GIST</dc:subject> <dc:subject>duodenum</dc:subject> <dc:subject>surgical treatment</dc:subject> <dc:subject>target therapy</dc:subject> <dc:title>Tumorile gastrointestinale stromale (gist) ale duodenului</dc:title> <dc:type>info:eu-repo/semantics/article</dc:type> </oai_dc:dc>
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