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Articolul urmator |
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Ultima descărcare din IBN: 2024-04-21 17:51 |
SM ISO690:2012 CORPACI, Cătălina, PATRAȘ, Elena, DRAGAN, Boris. Memory – from genetic mechanims to neuroplasticitaty. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 49. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Background. Learning and memory have proven to be fascinating mental processes because they address one of the fundamental features of human activity: our ability to acquire new ideas from experience and to retain these ideas over time in memory. (Erik. R. Kandel 2001). Objective of the study. This review describes cellular processes of synaptic plasticity, particularly functional and structural changes, initial memory acquisition, as well as mechanisms of short- and long-term memory storage. Material and Methods. A search strategy was developed, in which we included the abstracts of review articles of clinical trials, bibliographies, and books from databases like PubMed, and Wiley Online Library, etc. from the last 10 years. Results. It is generally acknowledged that the learning and memory processes are the result of the interplay between synaptic plasticity and orchestrated network activity that finally culminates in the long-term storage of information. The formation of long-term memory involves a series of molecular and cellular changes, including gene transcription, protein synthesis and synaptic plasticity dynamics. The neuroplasticity is dependent on a well-regulated program of neurotransmitter release, post-synaptic receptor activation, intracellular signaling cascades, gene transcription, and subsequent protein synthesis. Conclusion. The expedition into the neural basis of memory has been focusing on the molecular and cellular basis of activity-dependent plasticity, further the progress will require an approach that takes into consideration the importance of timing events in the CNS on every level of complexity. |
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Cuvinte-cheie Hebbian Theory, synaptic adaptation, pruning, proto-oncogenes, Teoria Hebbiană, adaptare, tăierea sinaptică, proto-oncogene |
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