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SM ISO690:2012 LEVCA, Anastasia, POGONEA, Ina. The principles of action of the hepatoprotective drugs. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 35. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Background. The liver is one of the most significant organs in the body which plays an essential role in such processes as the metabolism, secretion, storage, detoxification of endogenous and exogenous substances. Thus, hepatic diseases are one of the health-threatining issues to human lives. Objective of the study. The aim of the research was to study the hepatoprotective drugs and their principles of action. Material and Methods. Clinical and paraclinical data were taken form medical online articles and medical databases of patients from IMSP SCR. The prescribed hepatoprotective drugs and the frequency of the treatment in these cases were analyzed. Results. A promising prospect is represented by such hepatoprotective agents as: Anti-oxidants, N-acetylcystein, S Adenosyl Methionine, Herbal Medications and Silymarin. N-acetylcysteine prevents hepatic injury by restoring hepatic glutathione and improving hemodynamics and oxygen use. S Adenosyl Methionine is a precursor for glutathione which is an endogenous antioxidant that protects hepatocytes from injury by removing free radicals. Silymarin possesses membrane stabilizing, anti-oxidative, anti-fibrotic and immune-modulatory qualities. It activates RNA polymerase enzymes which leads to an increase of ribosomal formation. Thus, the protein and DNA synthesis is accelerated. Conclusion. The liver participates in a lot of biochemical processes in body, so the necessity of new and efficacious hepatoprotective drugs arises. Therefore, it is crucial to encourage the study of hepatoprotective drugs and their principles of action. |
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Cuvinte-cheie Hepatoprotective drugs, principles of action, Medicamente hepatoprotectoare, principii de acțiune |
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