Articolul precedent |
Articolul urmator |
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Ultima descărcare din IBN: 2024-02-26 05:35 |
SM ISO690:2012 MILICENCO, Alexandru, GLOBA, Tatiana. The role of chondrocyte apoptosis in the pathogenesis of osteoarthritis. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 22. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Background. Osteoarthritis is characterized by degeneration of articular cartilage. There are several molecular factors of chondrocyte apoptosis that contribute to the degradation of cartilage in osteoarthritis, but do not yet constitute therapeutic targets for its treatment. Objective of the study. Synthesis of bibliographic data to determine the molecular factors of chondrocyte apoptosis involved in the pathogenesis of osteoarthritis. Material and Methods. This research represents a detailed synthesis of bibliographic sources published abroad in scientific databases in the years 2015-2020. I have accesed the following search engines: PubMed, Google Scholar, Hinari. Results. Analyzing the bibliographic sources, the review articles performed at the international level, a series of molecular markers involved in the pathogenesis of osteoarthritis were highlighted: NO, caspase-1, -3, -6, -7, -8 and -9, tumour suppressor protein p53, MAPK, NFB, c-myc, death receptor Fas, C-terminal PARP-1 fragment, Toll-like receptors 1/2, TNF-, transforming growth factor beta, calcium-binding S100 proteins, matrix metalloproteinase-13, fibronectin, Bax, Bak, Bid, Bad, Bim, Bik, IL-1, leptin. Conclusion. The existence of a large number of molecular factors involved in the chondrocyte apoptosis offers a multitude of potential targets for pharmacological treatment of osteoarthritis. |
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Cuvinte-cheie osteoarthritis, chondrocyte, apoptosis, molecular factors, osteoartroza, condrocit, apoptoză, factori moleculari |
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