Many operative risk factors have been detected during the research based on somatofunctional status of patients with malignant tumors of genitals. Correct estimation of risk factors allows to carry out adequate preoperative preparation and provide patients’ safety during pre- and postoperative period. Success constituients during preoperative period among patients with neoplasms are: meticulous examination, correction of existing disturbances, adequate anesthesia method selection and during pre-, peri- and postoperative period.