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SM ISO690:2012 CONSTANTIN, Olga, CĂLCÎI, Cornelia, FEGHIU, Ludmila, CALISTRU, Iulia, CALISTRU, Andrei, HADJIU, Svetlana. Tratamentul profilactic al convulsiilor febrile la copii cu fenobarbital (continuu) în comparație cu diazepam (intermitent). In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 556. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Background. Febrile convulsions (CF) are a common phenomenon in childhood, with a frequency of 4-10% and a recurrence rate of 33-50%, depending on the age of debut of the first access, most often does not leave sequelae, and treatment prophylactic of relapses remains controversial. Objective of the study. To estimate the clinical efficacy of continuous phenobarbital therapy compared to intermittent diazepam medication, to assess the need to prevent recurrences of febrile convulsions. Material and Method. Prospective study, a group of 40 children (age 6 months - 5 years), selected in accordance with the critical clinic for simple or complex CF, who were hospitalized in the department of neurology and IMSP Mother and Child Institute . Of these, 22 children who used Diazepam as intermittent treatment during CF, 18 - received Phenobarbital as continuous treatment after febrile access. Results. Recurrences of seizures in CF in the group of children who used Diazepam (intermittent treatment) were found in 3 children (13.6%), and in the group of children with Phenobarbital (continuous treatment) - in 5 children (27.8%. The most common side effects of Phenobarbital were: hyperkinesia (5.6%), irritability (27.8%), cognitive impairment (22.2%), hypotension (11.1%) and anxiety (16.7%), and during intermittent treatment with Diazepam, no side effects were observed, except for sedation (13.6%). No significant difference (p> 0.05) was observed in the recurrence of CF in the administration of continuous and intermittent treatment. Conclusion. Continuous prophylactic treatment of CF with Phenobarbital generates adverse effects. Given the minor side effects of intermittent treatment with Diazepam, as well as the benign nature of CF, this method would be an optimal choice in CF prophylaxis. |
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Cuvinte-cheie Febrile convulsions, treatment, Diazepam, Phenobarbital, convulsii febrile, Tratament, Diazepam, Fenobarbital |
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Cerif XML Export
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Febrile convulsions (CF) are a common phenomenon in childhood, with a frequency of 4-10% and a recurrence rate of 33-50%, depending on the age of debut of the first access, most often does not leave sequelae, and treatment prophylactic of relapses remains controversial. Objective of the study. To estimate the clinical efficacy of continuous phenobarbital therapy compared to intermittent diazepam medication, to assess the need to prevent recurrences of febrile convulsions. Material and Method. Prospective study, a group of 40 children (age 6 months - 5 years), selected in accordance with the critical clinic for simple or complex CF, who were hospitalized in the department of neurology and IMSP Mother and Child Institute . Of these, 22 children who used Diazepam as intermittent treatment during CF, 18 - received Phenobarbital as continuous treatment after febrile access. Results. Recurrences of seizures in CF in the group of children who used Diazepam (intermittent treatment) were found in 3 children (13.6%), and in the group of children with Phenobarbital (continuous treatment) - in 5 children (27.8%. The most common side effects of Phenobarbital were: hyperkinesia (5.6%), irritability (27.8%), cognitive impairment (22.2%), hypotension (11.1%) and anxiety (16.7%), and during intermittent treatment with Diazepam, no side effects were observed, except for sedation (13.6%). No significant difference (p> 0.05) was observed in the recurrence of CF in the administration of continuous and intermittent treatment. Conclusion. Continuous prophylactic treatment of CF with Phenobarbital generates adverse effects. Given the minor side effects of intermittent treatment with Diazepam, as well as the benign nature of CF, this method would be an optimal choice in CF prophylaxis.</p></cfAbstr> <cfAbstr cfLangCode='RO' cfTrans='o'><p>Introducere. Convulsiile febrile (CF) reprezintă un fenomen deseori întâlnit în copilărie, cu frecvența de 4-10% și rata recurenței de 33-50%, în funcție de vârsta de debut al primului acces, de cele mai multe ori nu lasă sechele, iar tratamentul profilactic al recidivelor, rămâne controversat. Scopul lucrării. Estimarea eficacității clinice a terapiei continue cu fenobarbital, în comparație cu medicația intermitentă cu diazepam, pentru aprecierea necesității prevenirii recurențelor convulsiilor febrile. Material și Metode. Studiu prospectiv, pe un lot de 40 de copii (vârsta 6 luni – 5 ani), selectați în corespundere cu criteriile clinice pentru CF, simple sau complexe, care au fost spitalizați în secția de neurologie a IMSP Institutul Mamei și Copilului. Dintre aceștia, 22 copii au utilizat Diazepamul ca tratament intermitent în timpul CF, 18 – au administrat Fenobarbital ca tratament continuu după accesul febril. Rezultate. Recurențele acceselor convulsive, în cazul CF, în grupul copiilor care au utilizat Diazepamul (tratament intermitent) s-au atestat la 3 copii (13,6%), iar în grupul copiilor cu Fenobarbital (tratament continuu) – la 5 copii (27,8%). Cele mai frecvente reacții adverse ale Fenobarbitalului au fost: hiperkinezia (5,6%), iritabilitatea (27,8%), tulburările cognitive (22,2%), hipotensiunea (11,1%) și neliniștea (16,7%), iar în cadrul tratamentului intermitent cu Diazepam nu au fost observate reacții adverse, cu excepția sedației (13,6%). Nu a fost remarcată vreo diferență semnificativă (p>0,05) în recurența CF la administrarea tratamentului continuu și al celui intermitent. Concluzii. Tratamentul profilactic continuu al CF cu Fenobarbital generează efecte adverse. 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