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SM ISO690:2012 VASILACHE, Eugenia, CARACAŞ, Anastasia. Hepatotoxicitatea vitaminelor liposolubile A şi E. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 72. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Rezumat | ||||||
Background. The share of drug-induced liver diseases, caused by fat-soluble vitamins used uncontrollably, varies from 2 to 20 percent. Vitamins A and E, along with the beneficial effects, can exert toxic action on the liver manifested by hepatitis, non-cirrhotic portal hypertension. Objective of the study. To analyze reports of hepatotoxicity of fat-soluble vitamins A and E and to characterize the clinical and paraclinical aspects of liver damage when using vitamin preparations with elucidation of the mechanisms underlying liver toxicity. Material and Methods. A clinical case of administration of AEVIT 15 capsules / day for 2 years was analyzed (doses of vitamin E 1500 IU / day and vitamin A 1500000 IU / day). Results. The patient was hospitalized with the accusations: embarrassment in the right hypochondrium and epigastrium, weakness, dry skin, hair loss, abdominal distension, peripheral edema. Examination found: sclera jaundice, hepatomegaly ( + 1.5 cm) and splenomegaly ( + 3 cm ) , moderate increase in aspartate aminotransferase and alkaline phosphatase , hypoalbuminemia, and liver elastography - signs of cirrhosis. Liver biopsy: focal lobular hepatitis and enlarged, lipid-laden, stellate cells with varying degrees of sinusoidal fibrosis. Abdominal ultrasonography: signs of extrahepatic portal hypertension and signs of nonalcoholic steatosis. Conclusion. Portal hypertension in hypervitaminosis A and E is caused by obstruction of the perisinusoidal spaces Disse as a result of hyperplasia and hypertrophy of stellate cells stimulated by lipid vacuoles in the cytoplasm with collagen production and the development of perisinusoidal fibrosis |
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Cuvinte-cheie Vitamin A, vitamin E, drug hepatitis, hypervitaminosis, vitamina A, vitamina E, hepatită medicamentoasă, hipervitaminoză |
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Cerif XML Export
<?xml version='1.0' encoding='utf-8'?> <CERIF xmlns='urn:xmlns:org:eurocris:cerif-1.5-1' xsi:schemaLocation='urn:xmlns:org:eurocris:cerif-1.5-1 http://www.eurocris.org/Uploads/Web%20pages/CERIF-1.5/CERIF_1.5_1.xsd' xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' release='1.5' date='2012-10-07' sourceDatabase='Output Profile'> <cfResPubl> <cfResPublId>ibn-ResPubl-125687</cfResPublId> <cfResPublDate>2020</cfResPublDate> <cfStartPage>72</cfStartPage> <cfISBN></cfISBN> <cfURI>https://ibn.idsi.md/ro/vizualizare_articol/125687</cfURI> <cfTitle cfLangCode='RO' cfTrans='o'>Hepatotoxicitatea vitaminelor liposolubile A şi E</cfTitle> <cfKeyw cfLangCode='RO' cfTrans='o'>Vitamin A; vitamin E; drug hepatitis; hypervitaminosis; vitamina A; vitamina E; hepatită medicamentoasă; hipervitaminoză</cfKeyw> <cfAbstr cfLangCode='EN' cfTrans='o'><p>Background. The share of drug-induced liver diseases, caused by fat-soluble vitamins used uncontrollably, varies from 2 to 20 percent. Vitamins A and E, along with the beneficial effects, can exert toxic action on the liver manifested by hepatitis, non-cirrhotic portal hypertension. Objective of the study. To analyze reports of hepatotoxicity of fat-soluble vitamins A and E and to characterize the clinical and paraclinical aspects of liver damage when using vitamin preparations with elucidation of the mechanisms underlying liver toxicity. Material and Methods. A clinical case of administration of AEVIT 15 capsules / day for 2 years was analyzed (doses of vitamin E 1500 IU / day and vitamin A 1500000 IU / day). Results. The patient was hospitalized with the accusations: embarrassment in the right hypochondrium and epigastrium, weakness, dry skin, hair loss, abdominal distension, peripheral edema. Examination found: sclera jaundice, hepatomegaly ( + 1.5 cm) and splenomegaly ( + 3 cm ) , moderate increase in aspartate aminotransferase and alkaline phosphatase , hypoalbuminemia, and liver elastography - signs of cirrhosis. Liver biopsy: focal lobular hepatitis and enlarged, lipid-laden, stellate cells with varying degrees of sinusoidal fibrosis. Abdominal ultrasonography: signs of extrahepatic portal hypertension and signs of nonalcoholic steatosis. Conclusion. Portal hypertension in hypervitaminosis A and E is caused by obstruction of the perisinusoidal spaces Disse as a result of hyperplasia and hypertrophy of stellate cells stimulated by lipid vacuoles in the cytoplasm with collagen production and the development of perisinusoidal fibrosis</p></cfAbstr> <cfAbstr cfLangCode='RO' cfTrans='o'><p>Introducere. Ponderea afecțiunilor hepatice medicamentoase, cauzate de vitaminele liposolubile A şi E utilizate necontrolat, variază de la 2 la 20 la sută. Vitaminele A și E, de rând cu efectele benefice, pot exercita o acțiune toxică asupra ficatului manifestată prin hepatită, hipertensiune portală necirotică. Scopul lucrării. A identifica raportări de hepatotoxicitate a vitaminelor A şi E şi a caracteriza aspectele clinice şi paraclinice de lezare a ficatului la utilizarea preparatelor vitaminice cu elucidarea mecanismelor ce stau la baza toxicităţii asupra ficatului. Material și Metode. S-a analizat un caz clinic de administrare timp de 2 ani a preparatului AEVIT, 15 capsule/zi (doze de vitamina E 1500 UI/zi și vitamina A 1500000 UI/zi). Rezultate. La internare pacienta prezenta acuzele: jenă în hipocondrul drept și epigastru, slăbiciune, uscăciunea pielii, alopecie, distensie abdominală, edeme periferice. La examinare, s-a constatat: icterul sclerelor, hepatomegalie (+1,5cm) și splenomegalie (+3cm), creșterea moderată a aspartataminotransferazei şi fosfatazei alcaline, hipoalbuminemie, iar la elastografia hepatică – semne de ciroză. La biopsia ficatului: hepatită lobulară focală şi celule stelate lărgite, încărcate cu lipide, cu grade variabile de fibroză sinusoidală. La ultrasonografia cavității abdominale s-au constatat semne de hipertensiune portală extrahepatică şi semne de steatoză nonalcoolică. Concluzii. Hipertensiunea portală în hipervitaminoza A şi E este determinată de obturarea spațiilor perisinusoidale Disse în rezultatul hiperplaziei și hipertrofiei celulelor stelate stimulate de vacuolele lipidice din citoplasmă cu producerea de colagen și dezvoltarea fibrozei perisinusoidale.</p></cfAbstr> <cfResPubl_Class> <cfClassId>eda2d9e9-34c5-11e1-b86c-0800200c9a66</cfClassId> <cfClassSchemeId>759af938-34ae-11e1-b86c-0800200c9a66</cfClassSchemeId> <cfStartDate>2020T24:00:00</cfStartDate> </cfResPubl_Class> <cfResPubl_Class> <cfClassId>e601872f-4b7e-4d88-929f-7df027b226c9</cfClassId> <cfClassSchemeId>40e90e2f-446d-460a-98e5-5dce57550c48</cfClassSchemeId> <cfStartDate>2020T24:00:00</cfStartDate> </cfResPubl_Class> <cfPers_ResPubl> <cfPersId>ibn-person-71046</cfPersId> <cfClassId>49815870-1cfe-11e1-8bc2-0800200c9a66</cfClassId> <cfClassSchemeId>b7135ad0-1d00-11e1-8bc2-0800200c9a66</cfClassSchemeId> <cfStartDate>2020T24:00:00</cfStartDate> </cfPers_ResPubl> <cfPers_ResPubl> <cfPersId>ibn-person-39917</cfPersId> <cfClassId>49815870-1cfe-11e1-8bc2-0800200c9a66</cfClassId> <cfClassSchemeId>b7135ad0-1d00-11e1-8bc2-0800200c9a66</cfClassSchemeId> <cfStartDate>2020T24:00:00</cfStartDate> </cfPers_ResPubl> </cfResPubl> <cfPers> <cfPersId>ibn-Pers-71046</cfPersId> <cfPersName_Pers> <cfPersNameId>ibn-PersName-71046-2</cfPersNameId> <cfClassId>55f90543-d631-42eb-8d47-d8d9266cbb26</cfClassId> <cfClassSchemeId>7375609d-cfa6-45ce-a803-75de69abe21f</cfClassSchemeId> <cfStartDate>2020T24:00:00</cfStartDate> <cfFamilyNames>Vasilache</cfFamilyNames> <cfFirstNames>Eugenia</cfFirstNames> </cfPersName_Pers> </cfPers> <cfPers> <cfPersId>ibn-Pers-39917</cfPersId> <cfPersName_Pers> <cfPersNameId>ibn-PersName-39917-2</cfPersNameId> <cfClassId>55f90543-d631-42eb-8d47-d8d9266cbb26</cfClassId> <cfClassSchemeId>7375609d-cfa6-45ce-a803-75de69abe21f</cfClassSchemeId> <cfStartDate>2020T24:00:00</cfStartDate> <cfFamilyNames>Caracaş</cfFamilyNames> <cfFirstNames>Anastasia</cfFirstNames> </cfPersName_Pers> </cfPers> </CERIF>