| SM ISO690:2012|
DAVID, Adrian-Bogdan. Importanța proteinei C reactivă (CRP) în infecții ale sistemului respirator. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”. 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 36.
|Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020|
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" |
Chişinău, Moldova, 21-23 octombrie 2020
Background. CRP is a homopentamer protein, an acute phase reactant, present in tissue damage and inflammation. The mechanisms by which it activates the complement, induces apoptosis, phagocytosis, the production of NO and cytokines as well as the role of the isoforms mCRP and nCRP are not yet fully understood. Objective of the study. Analysis of laboratory results of CRP in patients with respiratory diseases to identify correlations between types of infections and also to appreciate the usefulness of isoform dosing. Material and Methods. Study of recent data on the dosing reasonableness of CRP isoforms. CRP dosing by agglutination method in four groups of patients (50 each): with pneumonia, tuberculosis, acute respiratory viral infection and a reference group, within the IMSP Republican Center for Medical Diagnosis. The study is descriptive, retrospective. Results. The most insignificant plasma concentrations of CRP were recorded in patients with tuberculosis (6-20 mg / L), median 10 mg / L, followed by the group with acute respiratory viral infection CPR (6-38 mg / L) median 18 mg / L. In patients with pneumonia the indicator is significant (6-96mg / L), the median 58mg / L.The nCRP isoform activates the classical complement pathway, induces phagocytosis and apoptosis has antiinflammatory and regenerative functions. The mCRP isoform promotes the chemotaxis of circulating leukocytes in areas of inflammation with antiapoptotic and proinflammatory effects. Conclusion. With varying intensity the amount of CRP increases in all respiratory infections. Biochemical analysis of CRP is effective for the diagnosis and monitoring of the infection. The dosage of the n and m isoforms of CRP would be reasonable and could serve as an indicator of effective treatment.
infection, CRP, respiratory system, isoforms,
infecţie, CRP, sistemul respirator, izoforme