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SM ISO690:2012 ABAEV, Rozalina. Efectele adverse ale tratamentului tuberculozei multidrog rezistente. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 275. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Pag. 275-275 | ||||||
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Background. Drug resistance threatens global tuberculosis control efforts. Objective of the study. In this study was to assess adverse reactions of second-line TB drugs in patients treated for MDR-TB at Institute of Phthisiopneumology “K. Draganiuc” in 2017. Material and Methods. The 107 patients were resistant to all first line drugs. Results. 72.9% of the patients were males and 27.1% were females. The mean of age was 37.1 years. The most common co-morbidities associated with MDR-TB in the studied cases were diabetes (29.9%). Side effects of drugs were; 57% GIT manifestations, 53.3% peripheral neuritis, hypokalemia 26.2%, irritable bowel syndrome 22.4%, ototoxicity 17.8%, skin reaction 10.3%, hypothyroidism 10.3%, hepatotoxicity 9.3%, hypoalbuminemia 5.6%, depression 3.7%, arthritis 0.9%, gynecomastia 2.8%, hyponatremia 5.6%, hypomagnesaemia 1.9%, dizziness 0.9%, nephrotoxicity 3.7%. Most of the drugs’ side effects started to appear within the first 3 months of treatment. Conclusion. The most common type of resistance is acquired resistance because of lack of adherence to treatment or inappropriate treatment. The most common side effects of MDR TB treatment were gastrointestinal manifestations. Most side effects occurred within the first 3 months of treatment. |
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Cuvinte-cheie Multidrug Resistant Tuberculosis, side effects, tuberculoză multidrug rezistentă, efecte adverse |
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