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Ultima descărcare din IBN: 2023-03-26 12:30 |
SM ISO690:2012 BIVOL, Elena, GRIB, Liviu, SASU, Boris, VLASOV, Lilia, GRĂJDIERU, Romeo, GRAJDIERU, Alexandra. Valoarea prognostică a ecuațiilor de estimare a funcției renale în sindromul cardiorenal de tip 2. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 186. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Pag. 186-186 | ||||||
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Background. Renal function worsening is often observed in chronic heart failure (CHF). Glomerular filtration rate (GFR) is widely accepted as a marker for renal function evaluation, and usually, is estimated with the use of creatinine-based formulas. Objective of the study. To compare the prognostic value of estimating glomerular filtration rate formulas in type 2 cardiorenal syndrome. Material and Methods. A total of 170 consecutive hospitalized CHF patients with intermediate or reduced ejection fraction and renal changes (51.8 % men, age 68.33 ± 1.06 years) were studied. Renal function and glomerular filtration rate (GFR) was assessed using the most popular formulas for GFR estimation: the Cockcroft-Gault (CG), the sMDRD formula, CKD-Epi formulas, and the simple cystatin-C formula. Results. During 6 months follow-up, 29 (16.2%) deaths were recorded. Renal biomarkers and estimated GFR showed different prognostic value. AUC was 0.58 (95% CI:0.47-0.69, P = 0.05) for creatinine, 0.67 (95% CI: 0.56-0.79, P< 0.05) for cystatin-C; 0.76±0.05 (95% CI: 0.67 - 0.82, P< 0.01) for CKD-EPI formula based on serum cystatin-C; 0.73 ±0.06 (95% CI: 0.65 - 0.79, P< 0.01) for simple cystatin-C formula; 0.72±0.05 (95% CI: 0.64- 0.79, P< 0.01) CKD-EPI formula based on cystatin-C and creatinine; 0.617±0.06 (95% CI: 0.53 - 0.69, P< 0.01) CKD-EPI based on serum creatinine; 0.615±0.06 (95% CI: 0.53 - 0.69, P< 0.01) for sMDRD and 0.58±0.07 (95% CI: 0.53 - 0.69, P< 0.01) for CG. Conclusion. GFR is an independent predictor for short term mortality of type 2 cardiorenal syndrome. Cystatin-C based formulas for GFR estimation offer improved prognostication in this population, while CG formula, serum cystatin-C and serum creatinine fail to predict short term mortality. |
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Cuvinte-cheie Cardiorenal syndrome, prognostic, cystatine-C, sindrom cardiorenal, prognostic, cistatina-C |
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