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616.72-002.77-053.2:577.161.2 (1) |
Patologia organelor de locomoţie. Sistemul osos şi locomotor (469) |
Bazele materiale ale vieții. Biochimie. Biologie moleculară. Biofizică (664) |
SM ISO690:2012 FOCA, Silvia-Gabriela, REVENCO, Ninel. Evaluarea statutului metabolismului osos la copii cu maladii reumatice prin aprecierea 25-OH vitaminei D totale in ser. In: Buletin de Perinatologie, 2020, nr. 4(89), pp. 25-32. ISSN 1810-5289. |
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Buletin de Perinatologie | ||||||
Numărul 4(89) / 2020 / ISSN 1810-5289 | ||||||
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CZU: 616.72-002.77-053.2:577.161.2 | ||||||
Pag. 25-32 | ||||||
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Introduction. As a consequence of the chronic infl ammatory process, children with rheumatic conditions can present with both - variable degree of joint pain and limitation of the range of motion, the last one, sometimes being followed by ankylosis. Aim: Assessment of serum level of 25-OH vitamin D in children with rheumatic conditions and glucocorticoteroid treatment (GCS). Material and methods: Twenty four (24) children with confi rmed rheumatic conditions treated with systemic glucocorticosteroids were included in the study. All the patients received GCS, with an average duration of 28,02±27,74 months. The assessment of 25-OH vitamin D was done through immunoenzymatic assay. Results: Th e average value of total serum 25-OH vitamin D in children included in the study was 14,57±5,66 ng/ml. Suboptimal level was detected in 51,72% of children (range 20-50 ng/ml). Importantly, in children with juvenile idiopathic arthritis average level of vitamin D was 135±63,87ng/ml. Patients with connective tissue diseases had an average level of total serum vitamin D of 12,44 ±5,25 ng/ml. Conclusions: These findings could serve as a base for recommendations aiming the prevention of vitamin D deficiency in patients with chronic rheumatic conditions. |
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Cuvinte-cheie Juvenile idiopathic arthritis, vitamin D, chronic rheumatic diseases in children, идиопатический ювенильный артрит, витамин Д, хронические ревматологические заболевания, дети |
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