The results of the resistance monitoring of the two-spotted spider mites, thrips, greenhouse whitefly and aphids to pesticides in vegetable glasshouses of the Kishinev region are given. The resistance of Tetranychus urticae.urticae Koch, Trialeurodes vaporariorum Westw., Frankliniella sp. populations to organophosphates and pyrethroids are established. The tolerances of T. vaporariorum Westw.and Frankliniella sp. to neonicotinoids are demonstrated. The main direction of the resistance management of greenhouses pests to pesticides is the elaboration of complex protection systems. These systems have to include the novel insectoacaricides, hormonal chemicals, and biological control agents.