Numerous studies made worldwide have indicated that treated and untreated wastewater entering surface waters contains illicit drugs, as a result of human consumption and excretion, illicit manufacturing processes and improper disposal. The results indicate that these wastes, and hence the drugs of abuse exposure, influences the plants and animals and the associated health of streams. The hallucinogenic 2C-x and DOx amphetamines are synthetic psychotropic drugs that have been increasingly reported in seizures, especially in Europe and the US. This paper presents a new combination of artificial intelligence techniques that improves the celerity of the detection of these illicit drugs based on their ATR-FTIR spectra, while decreasing the required computational resources.