Introduction. Gastro esophageal reflux disease (GERD) is a common health problem nowadays. GERD strongly affects the quality of patients’ life and increases the risk for esophageal adenocarcinoma, affects the public health and leads to a permanent increase of economic burden. At the same time, all over the world, a huge number of people are infected with viral hepatitis B, and nearly 400 million are chronic carriers of this virus. Thus, viral hepatitis B is still a serious danger regarding public health. Aim of the stu dy. To discover the relationship and possible interactions between this two entities. Materials and methods. Our study has evaluated a group of 321 outpatients, 93 (28,9%) were diagnosed with GERD. From 197 with viral hepatitis 56 (28,4%) have associated GERD. Results. Out of 131 patients with viral hepatitis B, 53 (40,46%) had GERD. This last group (patients with GERD and chronic viral hepatitis) were analyzed more detailed, in order to look for the possible risk factors (such as increased body mass inde x, infection with Helicobacter pylori, sex, and age), concomitant diseases or other factors which could elucidate how viral hepatitis B can lead to appearance or aggravation of GERD. Additional, we have studied a group of patients just with GERD, without a ny hepatic pathology, in order to see the difference between these two groups. Conclusions. Our data suggest a significant association between chronic viral hepatitis and GERD.