In red wines from grapes grown in Moldova, polyphenols, which have a pronounced antioxidant activity are represented mainly monomeric anthocyanins and their derivatives (cianidina, delphinidin, peonidina, petunidina), flavonoids (quercetin and rutin) and stilbenes (resveratrol). Using high performance liquid chromatography (HPLC) determines differently principal monomeric polyphenols content, resveratrol, quercetin and routine dry red wine grapes. Separation schemes developed can be successfully used to study phenolic compounds in wine during various investigations. Were studied stilbene compounds in red wine grape grown in Moldova, the different years of harvest, from different manufacturers. It was found that the content of these compounds in wines analitzate are: quercetin (0.4 to 107) mg/dm3, routine - (0.7 to 14.6) mg/dm3, rezveratrol - (1.2 to 9.5) mg/dm3. Concentrations, these substances contained in red wine Moldovan allow sufficient to assume their biological activity because, according to the statements of many scholars, namely the group of polyphenols act as antioxidants and antimutagenic human body.