This article is investigating some relevant aspects considering structural changes of the land fund in the Republic of Moldova. Also it is considering the structure evolution of land fund along 2007-2009 years. The results of the research conclude that one of the most important rise components of efficient usage of land fund is spread of fertilizers according to settled standards by scientific research institutions. Economical efficacy using the land fund may be provided by supplying the agricultural enterprises with modern equipment (creating technological stations and machines), fertilizers spread, performing all agricultural ground according to scientific recommendations. Soil erosion and landslides are a big and risky danger bringing a huge loss to economy, population, diminishing the land fund of the Republic of Moldova. Land is becoming wealth and valuable just being carefully and wisely looked after.