Synthesis, Structure, and Biological Activity of Mixed-Ligand Amine-Containing Copper(II) Coordination Compounds with 2-(2-Hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide

Gulya Aurelian; Graur Vasilii О.; Ulchina Ianina; Bourosh Pavlina; Smaglii Vadim; Garbuz Olga; Tsapkov Victor I.

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GULYA, Aurelian, GRAUR, Vasilii О., ULCHINA, Ianina, BOUROSH, Pavlina, SMAGLII, Vadim, GARBUZ, Olga, TSAPKOV, Victor I.. Synthesis, Structure, and Biological Activity of Mixed-Ligand Amine-Containing Copper(II) Coordination Compounds with 2-(2-Hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide. In: Russian Journal of General Chemistry, 2021, vol. 91, pp. 98-107. ISSN 1070-3632. DOI: https://doi.org/10.1134/S1070363221010114

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Russian Journal of General Chemistry

Volumul 91 / 2021 / ISSN 1070-3632 /ISSNe 1608-3350

Synthesis, Structure, and Biological Activity of Mixed-Ligand Amine-Containing Copper(II) Coordination Compounds with 2-(2-Hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide

DOI:https://doi.org/10.1134/S1070363221010114

Pag. 98-107

Gulya Aurelian¹, Graur Vasilii О.¹, Ulchina Ianina¹, Bourosh Pavlina², Smaglii Vadim³, Garbuz Olga¹⁴, Tsapkov Victor I.¹

¹ Moldova State University,
² Institute of Applied Physics,
³ Institute of Chemistry,
⁴ Institute of Zoology

Proiecte:

20.80009.8007.03 Noi substanțe cu potențial preventiv și terapeutic în baza compușilor naturali de origine vegetală și a matodelor moderne de sinteză organică

Disponibil în IBN: 6 aprilie 2021

Rezumat

Abstract: Сopper(II) nitrate reacts in ethanol with 2-(2-hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide H₂L in an 1 : 1 molar ratio to form the coordination compound Cu(HL)NO₃·H₂O. The introduction of amines [imidazole (Im), 3,5-dibromopyridine (3,5-Br₂Py), and 4-methylpyridine (4-Pic)] into the reaction mixture in a molar ratio 1 : 1 : 2 leads to the formation of CuA(HL)NO₃·nH₂O [A = Im, 3,5-Br₂Py, 4-Pic; n = 0, 3] complexes. The structure of the obtained compounds was determined by X-ray structural analysis. The synthesized complexes exhibit antimicrobial, antifungal, antioxidant, and anticancer activities.

Cuvinte-cheie
Amines, anticancer activity, Antimicrobial activity, Cu(II) coordination compounds, salicylaldehyde 4-allylthiosemicarbazone

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<creatorName>Bouroş, P.N.</creatorName>
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<creatorName>Smaglii, V.A.</creatorName>
<affiliation>Institutul de Chimie, Moldova, Republica</affiliation>
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<title xml:lang='en'>Synthesis, Structure, and Biological Activity of Mixed-Ligand Amine-Containing Copper(II) Coordination Compounds with 2-(2-Hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide</title>
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<subject>Amines</subject>
<subject>anticancer activity</subject>
<subject>Antimicrobial activity</subject>
<subject>Cu(II) coordination compounds</subject>
<subject>salicylaldehyde 4-allylthiosemicarbazone</subject>
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<description xml:lang='en' descriptionType='Abstract'><p>Abstract: Сopper(II) nitrate reacts in ethanol with 2-(2-hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide H<sub>2</sub>L in an 1 : 1 molar ratio to form the coordination compound Cu(HL)NO<sub>3</sub>&middot;H<sub>2</sub>O. The introduction of amines [imidazole (Im), 3,5-dibromopyridine (3,5-Br<sub>2</sub>Py), and 4-methylpyridine (4-Pic)] into the reaction mixture in a molar ratio 1 : 1 : 2 leads to the formation of CuA(HL)NO<sub>3</sub>&middot;nH<sub>2</sub>O [A = Im, 3,5-Br<sub>2</sub>Py, 4-Pic; n = 0, 3] complexes. The structure of the obtained compounds was determined by X-ray structural analysis. The synthesized complexes exhibit antimicrobial, antifungal, antioxidant, and anticancer activities.&nbsp;</p></description>
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