Articolul precedent |
Articolul urmator |
702 6 |
Ultima descărcare din IBN: 2023-10-20 10:02 |
SM ISO690:2012 ANDRONACHE, Lilia, GUDUMAK, V., GULYA, Aurelian, TAGADIUC, Olga, GARBUZ, Olga, PANTEA, Valeriana. New inhibitors of glycation and of the formation of advanced glycation end products. In: Physical Methods in Coordination and Supramolecular Chemistry, 8-9 octombrie 2015, Chişinău. Chisinau, Republic of Moldova: 2015, XVIII, p. 33. |
EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
Physical Methods in Coordination and Supramolecular Chemistry XVIII, 2015 |
||||||
Conferința ""Physical Methods in Coordination and Supramolecular Chemistry"" Chişinău, Moldova, 8-9 octombrie 2015 | ||||||
|
||||||
Pag. 33-33 | ||||||
|
||||||
Descarcă PDF | ||||||
Rezumat | ||||||
Background. The accumulation of advanced glycation end-products (AGEs) due to non-enzymatic glycation of proteins is specific for various diseases associated with aging and diabetes melitus, particularly for diabetic complications. AGEs formation changes the structure and function of long-living proteins, especially structural proteins such as collagen and elastin, which contributes to the development and worsening of chronic degenerative aging-related diseases and cancer. These products have numerous biologic effects stimulate the secretion of cytokines and adhesion molecules, contribute to the release of growth factors, enhance the proliferation, migration and invasion of cancer cells, increase the vascular and myocardial stiffness involved in the development of chronic complications of diabetes, damage the vascular endothelium and induce the development of cardiovascular diseases [1]. These considerations have prompted the search for AGE inhibitors. Prevention and treatment strategies include prevention of AGEs cross-links formation and their destruction by cross-links breakers [1, 2]. Thus, is of great interest to study the influence on the processes of AGEs formation of the local bioactive compounds (BC) – new Schiff bases and their combination with 3d metals exhibiting important bioactive properties [3]. |
||||||
|