The interaction of inorganic glasses with acid gases has been investigated for more than one hundred years. The nature of the reaction of industrial glassware with fluorine-containing reagents has been insufficiently studied. The aim of the undertaken experiments was to determine the factors affecting the process of dealkalization of industrial glassware with fluorine– and chlorine–containing reagents. The subjects of investigation were various types of industrial glassware: sheet glass samples, containers (bottles, jars and flasks) of colorless glass, bottles and flasks of green glass, ampoules made from medical glass, insulators from alcali-free glass, illuminating glassware made from transparent colorless and milk glasses, laboratory and assorted glassware etc. Difluorodichloromethane and difluorochloromethane and mixtures of these reagents with sulfur dioxide were used for the chemical treatment of glass. Experiments were held in laboratory and industrial conditions. The main regimes of thermochemical treatment of glass samples are: temperature - between 20 and 700 oС, duration between 1 s and 2 h, quantity of gaseous reagent introduced into the reacting vessel - between 0.01 and 1.00 mol. The intensity of glass dealkalization by gaseous reagents was characterized by the rate of extraction of alkaline cations. We have investigated the influence of the following factors on the process of dealkalization of industrial glasses with fluorine– and chlorine–containing reagents: temperature, chemical compositions of the gas medium, duration of the thermochemical treatment, concentration and humidity of gaseous reagent, repeated thermal treatment, surface state of the samples, the action of the electric and magnetic fields etc. Treatment of industrial glassware with fluorine– and chlorine–containing reagents at temperatures above 300 0C is accompanied by extraction of alkali metal cations from glass. Reagents extracted cations of alkaline earth metal from insulator alkaline free glass. In laboratory conditions when temperature increases up to 600 oC, the extraction rate of alkaline metals cations from industrial glasses grows by 10-25 times. The mixtures of fluorine– and chlorine–containing reagents with sulfur dioxide most actively dealkalized industrial glasses. When increasing the duration of thermochemical treatment, the concentration and humidity of fluorine– and chlorine–containing reagents, the extraction rate of alkali metal cations from industrial glass grows. The repeated thermal treatment practically does not change the dealkalization rate of glass by gaseous reagents. The newly-formed hot glassware is more actively dealkalized by reagents than that stored and used. The use of electric and magnetic fields increases the extraction rate of alkali metal cations from industrial glass by several times. We have developed the optimal regimes of thermochemical treatment of industrial glassware with fluorine– and chlorine–containing reagents in laboratory and industrial conditions.