Relationship between the nitrogen mineral forms and organic carbon in natural surface waters is very complex. The research of natural surface waters denotes high correlation coefficients for COD-Mn (0.9714), COD-Cr (0.9872) and running time of process which requires the evidence of organic pollutants that indeed inhibit the process [1]. The soluble extracts of Methylococcus Capsulatus, which readily oxidize methane to methanol, oxidize ammonia to nitrite through hydroxylamine. The activation of ammonia oxidation requires O2. Oppositely, the presence of specific inhibitors of methane monooxygenase activity inhibits readily this oxidation process [2]. The kinetics of ammonia oxidation as well as the capacity of ammonia to be oxidized by the marine bacterium Nitrosococcus Oceanus has been investigated in order to study the oxidation of methane. The oxygen concentration has a different effect: it reduces the inhibition rate for high concentrations of substrate (methane) and increases it at low concentrations. The contribution of consumption of methane to the total assimilated carbon varies directly with the percentage relation [CH4] / [NH3] and can be significant in a dilute aquatic environment. The capacity of the ammonia oxidation was inhibited by high concentrations of organic substrates and it was the highest in the poorest medium [3]. The action of cationic surfactants (TASKt) on nitrification processes differs from anionic (TASAn) and non-ionic surfactants (TASN). At the maximum allowable concentrations (MACs) TASAn and TASN stimulate the ammonia oxidation, while TASKt blocks this phenomenum. TASAn and TASN separately and together diminish the effect of blocking the ammonia oxidation by TASKt. MACs of petroleum products block the nitrification of NH4 + ions in 10 days. The humic acids neutralize the negative influence of petroleum products on the dynamic of oxidation of nitrogen reduced forms in water. Urea, anionic surfactants and phenol in mixtures with petroleum products affect negatively the oxidation process, but all these substances taken in the mixture with humic acids have a reverse action. In the presence of aliphatic amines at the MAC, the time of ammonia oxidation increases with the decrease of the number of carbon atoms in aliphatic radicals and the number of radicals themselves (trimethylamine, diethylamine, dimethylamine, methylamine). For aromatic amines, the oxidation time increases in following consequence: diphenylamine, aniline, phenylenediamine, naphthylamine, phenylhydrazine. So, the relationship C:N in surface waters preserves research opportunities.