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SM ISO690:2012 BAIRAK, N.. Synthesis and Anti-proliferative Activity of Coordinative Combination of Copper, Cobalt, Nickel and Zinc with 2-acetylpyridine Semi- and Thiosemicarbazone and their 4-Phenyl Substituents. In: French-Romanian Colloquium on Medicinal Chemistry, Ed. 4, 30-31 octombrie 2014, Iași. Iași : “Alexandru Ioan Cuza” University of Iasi, 2014, Ediţia 3, p. 227. 10.2478/achi-2014-0015 |
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French-Romanian Colloquium on Medicinal Chemistry Ediţia 3, 2014 |
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Colocviul "3rd French-Romanian Colloquium on Medicinal Chemistry" 4, Iași, Romania, 30-31 octombrie 2014 | ||||||
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Pag. 227-227 | ||||||
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It is well known that many semi- and thiosemicarbazide derivatives display biologic activity and are widely used in medicine in treating infections caused by different microorganisms. Many of these substances form with the salts of transition metals coordination compounds that display physiological activity, and can be examined as preparations with biochemical and pharmacologic application. Thus, the synthesis and study of new coordination compounds of bio-metals with semiand thiosemicarbazide derivatives are of scientific and practical interest. The aim of the given paper is to establish optimum conditions of synthesis, structure, physicochemical and biological properties of cobalt, nickel, copper and zinc coordination compounds with semicarbazone (L1 ), 4-phenylsemicarbazone (L2 ), thiosemicarbazone (L3 ), and 4phenylthiosemicarbazone (L4 ) 2-acetylpyridine. First were synthesized the L1 -L4 compounds, whose synthesis scheme can be presented in the following way: + E t O H / t H2 O H2 N N H C O N H R ( S ) N C N C H3N H CO ( S ) N H R N C O C H3 where R=H, C6 H5 Then, the interaction of ethanol solutions of chloride, bromide, copper (II) nitrate and sulphate with the L 1 – L4 , taken in 1:1 molar ratio led to microcrystalline substances for which the compositions CuL1-4 X2 (X = Cl, Br, NO3 , 1/2SO4 ) were determined on the basis of elemental analyses data. However, when copper salts are replaced with chloride, bromide, nitrate, acetate of cobalt, nickel and zinc, the reaction results in substances with the composition M(L1-4 -H) 2X. Comparing the IR spectra of the initial semi- and thiosemicarbazones with those of the synthesized complexes showed that the L1-4 act as monodeprotonated tridentate N,N,O (for L1,2 ) and N,N,S (for L3,4 ) ligands and coordinate to central atoms through the atoms of pyridinic and azomethinic nitrogen and oxygen (for L 1,2 ) or sulphur (for L3,4 ). Furthermore, indentifying the anti-proliferative activity of the synthesized complexes was of high interest. It was found that the copper complexes of these ligands inhibit the growth of myeloid leukemia cells, and that a 4-phenyl substituent increase the activity. For 4-phenyl semicarbazone 2acetylpyridine high activity is also manifested for cobalt and nickel complexes (in comparison with the medicine - doxorubicine - used currently in the medical science for treating and preventing leucoses). |
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