Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
90 0 |
SM ISO690:2012 VICĂ, Mihaela Laura, DOBREANU, Minodora, KUROCHKIN, G. S., MATEI, Horea Vladi, BÂLICI, Ștefana, VUȘCAN, Mihaela Elvira, CHIOREAN, Alin Dan, NICULA, Gheorghe Zsolt, PAVEL MIRONESCU, Daniela Cristina, LEUCUȚA, Daniel Corneliu, TEODORU, Cosmin Adrian, SISERMAN, Costel. The Influence of HLA Polymorphisms on the Severity of COVID-19 in the Romanian Population. In: International Journal of Molecular Sciences, 2024, vol. 25, pp. 1-16. ISSN 1661-6596. DOI: https://doi.org/10.3390/ijms25021326 |
EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
International Journal of Molecular Sciences | |
Volumul 25 / 2024 / ISSN 1661-6596 /ISSNe 1422-0067 | |
|
|
DOI:https://doi.org/10.3390/ijms25021326 | |
Pag. 1-16 | |
Descarcă PDF | |
Rezumat | |
In this study, we aimed to investigate whether specific HLA alleles found in patients from Romania and the Republic of Moldova were associated with the severity of COVID-19 infection and its associated mortality. We analyzed the HLA alleles at the -A, -B, -C, -DRB1, and -DQB1 loci in a cohort of 130 individuals with severe and extremely severe forms of COVID-19, including 44 individuals who died. We compared these findings to a control group consisting of individuals who had either not been diagnosed with COVID-19 or had experienced mild forms of the disease. Using multivariate logistic regression models, we discovered that the B*27 and B*50 alleles were associated with an increased susceptibility to developing a severe form of COVID-19. The A*33 and C*15 alleles showed potential for offering protection against the disease. Furthermore, we identified two protective alleles (A*03 and DQB1*02) against the development of extremely severe forms of COVID-19. By utilizing score statistics, we established a statistically significant association between haplotypes and disease severity (p = 0.021). In summary, this study provides evidence that HLA genotype plays a role in influencing the clinical outcome of COVID-19 infection. |
|
Cuvinte-cheie adult, allele, article, clinical outcome, controlled study, coronavirus disease 2019, female, genotype, haplotype, HLA system, human, human cell, major clinical study, major histocompatibility complex, Male, middle aged, Moldova, prevention, Romania, Severe acute respiratory syndrome coronavirus 2, Severity of Illness Index |
|
|