Introduction. Although not always harmful, polypharmacy is a growing concern for rehabilitation physicians as it presents an increased risk of undesirable effects for patients with multimorbidity that may affect the rehabilitation management. Material and Methods. A total of 50 medical records and prescription lists of poststroke patients enrolled in rehabilitation programs were analysed in order to identify the number of medicines prescribed and their potential harmful combinations. Results. The study showed that the number of medical conditions in post-stroke patients varied from 4 to 11; hypertension, diabetes, atrial fibrillation or arthrosis being the most common. The number of medications prescribed to patients ranged from 5 to 12. Analysis of drug combinations prescribed for pharmacological treatment of medical conditions such as pain, spasticity, incontinence and others, revealed a lot of undesirable combinations. Some of these potential dangerous combinations have been identified and discussed. Conclusions. Rehabilitation physicians have to analyze carefully the medicines combinations used for pharmacological treatment during rehabilitation post-stroke patients. Some of them can have drug interactions that may potentially lead to ineffective pharmacological treatment, side effects and negative impact on patient balance, coordination and finally increase a risk of falls. It is important to apply only acceptable combinations of medicines, or take into account the priority in solving medical problems encountered in rehabilitation of post-stroke patients. In some cases the number of medications may need to be reduced, and alternative treatments may need to be considered.