Introduction. Suppurative granuloma is part of the granulomatous conditions that represent a group of diseases with varied etiology and clinical manifestations, which have in common the formation of granulomas on the skin or other organs, revealed only in the histopathological examination. The name granuloma comes from the Latin language-granulum (granule), -oma (result of an action), and from a histopathological point of view it is defined as an organized collection of histiocytes. Depending on the histopathological appearance, granulomatous conditions can be divided into five categories: epithelioid granulomas, tuberculoid granulomas, palisade granulomas, suppurative granulomas and foreign body granulomas. Material and methods. We present the case of a male patient, 64 years old, from a rural environment, diagnosed with this disease. Pacient relates that is sick for 6-7 months. The onset of the disease was slow, according to the patient, he went to ophthalmology with a tumor on the upper eyelid (chalazion). After the surgical removal of the tumor, the complication described in the presentation occurred. Differential diagnosis: Squamous cell epithelioma, basal cell epithelioma, lipoid necrobiosis, herpes zoster, deep mycosis, chronic erysipelas, amelanotic malignant melanoma. Complex treatment was administered: cortisone therapy according to the schedule, nonsteroidal anti-inflammatory drugs, short courses of antibiotic therapy, desensitizers, vitamin therapy. Conclusions. Periorbital suppurative granuloma is a very rare form, the diagnosis is established only after a morphological examination. This state of granulomatous inflammation occurs in patients with allergic predispositions. Treating this condition is difficult and requires long time therapy.