Introduction. Diabetes mellitus (DM) is a chronic disease with increasing prevalence over the past decades. This makes vital to identify the risk factors. Last years was underlined the importance of uric acid (UA), which has an important role in the onset of DM and its complications. Material and methods. The study included 60 diabetic patients divided in: I group -30 with type 1 DM and II group - 30 with type 2 DM, hospitalized in SCR „Timofei Mosneaga”, between 01.01.22 and 19.10.22. Results. The average age in the I group is 41.65±14.77 and in the II group is 60.86±6.57. Serum UA levels were categorized into normal <214 μmol/l and high >214 μmol/l. The first group had normal UA - 46.6% and high UA - 53.4%, in the second group 13.33% presented normal UA and 86.6% high level. Also, was analyzed the relation between UA and GFR, which reveal the correlation between them: for the first group: R=0.56 and P= 0.00128 and for the second one: R= -0.59 and P= 0.0005. Conclusion. The high level of UA was found in patients with DM, especially in type 2 DM (86.6% vs. 53.4%). A significant negative association was observed between serum UA and GFR. UA monitoring is important aim for prevention DM’s complications, especially the renal one.