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SM ISO690:2012 PADUCA, Ala, CARDANIUC, Corina, SURGUCI, Mihail, MĂMĂLIGĂ, Vitalie, FONARIUC, Ludmila, BÎTCĂ, Tamara. Efectele terapiei hormonale de substituţie asupra funcţiei lacrimale şi sindromului ochiului uscat. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2012, nr. 4(13), pp. 376-379. ISSN 1857-1719. |
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Analele Ştiinţifice ale USMF „N. Testemiţanu” | ||||||
Numărul 4(13) / 2012 / ISSN 1857-1719 | ||||||
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Pag. 376-379 | ||||||
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The effects of hormonal replacement therapy on
tears function and dry eye syndrome
Dry eye syndrome, or keratoconjunctivitis sicca, damages the ocular surface and can cause debilitating symptoms of dryness and irritation, which may result in psychological comorbidity and reduced work capacity. Importantly, chronic dry eye can have a serious impact on quality of life of women and may increase the risk for permanent loss of vision or recurrent infections. In post-menopausal women endocrine changes join the aging effects in the pathogenesis of dry eye, but still it remains controversial whether estrogen or androgen deficiency or their imbalance impair ocular surface function. Another questionable issue concerns the efficacy of hormonal replacement therapy in the amelioration of dry eye symptoms and recovery of tear function, since the scientific literature stands in between a therapeutic or a promoting effect of eye dryness. The aim of the present study was to evaluate the effects of hormonal replacement therapy on tears function and dry eye syndrome. Our results indicate that the use of postmenopausal women who use HRT have a higher prevalence of dry eye syndrome compared with those who have never used HRT, and this is particularly true of women who used estrogen alone. |
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