This article summarizes the research of the practical aspects of the implementation of the internal and external policy of the Republic of Moldova regarding the management of the state border, as well as the impact on cross-border cooperation. From the analysis of the role, the place of the state border, the peculiarities of its management within different systems, it is concluded that border security, the stimulation and promotion of cross-border cooperation, as well as the development of the territories of the border areas are interdependent compartments of the state policy of the Republic Moldova, which promotes good neighborly and friendly relations with neighboring countries. At the same time, the success of the policies addressed will essentially contribute to the achievement of the country's strategic objective - joining the European community space.