The wealth disparities between European countries are particularly evident in border regions, which affects cross-border cooperation and relations. The process of cluster development in the border area can be considered as one of the new challenges of cross-border cooperation, which is currently evolving from a bilateral partnership to a network model. Clusters are used for cooperation between institutions within a certain geographical area, which provides an opportunity to initiate and develop direct contacts between network participants. In the sustainable development of the border, both the social and economic aspects of development should be considered. Therefore, finding ways to promote the development of crossborder entrepreneurship based on existing forms of cross-border cooperation, including cooperation in the social sphere, is an important research problem. An important obstacle to the development of cross-border cooperation was the Covid-19 pandemic, which led to a systematic closure of national borders around the world and significantly affected the nature of cross-border cooperation in Europe, including the Polish-Czech-Slovak border. The aim of the article is to analyse cross-border cooperation using the example of PolishCzech-Slovak cross-border cooperation between the Opole and Silesian Voivodeships (Poland), the Moravian-Silesian Region (Czech Republic) and the Žilina Region (Slovakia). The article examines whether the cluster can be an advanced way to develop the sustainable cross-border corporation.