The purpose of the research is to study the impact of digitization and the spread of digital platforms (DP) on the transformation of the institutional environment of human economic activity. The research is based on the comprehensive use of structural, functional, systemic, complementary institutional, historical-genetic, graphic analysis. Institutional transformation is considered at mega-, macro-, meso-, micro- and nano-economic levels. The impact of platformization on the change of organizational structures for ensuring global, regional and sectoral economic interaction and institutional forms of its implementation is presented. It is shown that the formation of DP at the microeconomic level as an alternative to traditional hierarchical structures leads to a radical restructuring of the institutional structure of entire sectors of the economy. It was started by transport (passenger and cargo transportation), hotel and tourist business. It is substantiated that the consequence of the spread of the platform business model at the mesoeconomic level was the transition from chains to networks of value creation, ecosystems-2. They include all stages of value creation in a single production cycle. At the macroeconomic level, the duplication of individual elements of networks ensures their approximation to sales markets. Accelerates the process of implementation of additive technologies and the COVID-19 pandemic. The tendency of developing countries to lose the advantages of cheap labor is accelerating. Countries with developed economies are reindustrializing. At the global level, the regionalization of world trade is combined with the preservation of the global nature of production systems. The transformation of the global production system leads to changes in the institutional support of global trade, transport logistics, financial, currency, and investment relations. The institutional mechanism of the formation of network ecosystems by DPs and their influence on the transformation of relations between economic subjects is disclosed. Attention is focused on the study of the influence of DPs on the fundamental revision of property relations, the system of corporate governance, industrial relations, competitive interaction, and the tools of state regulation of business.