Backgraund: Recent studies show the fact that sepsis and systemic inflammatory response syndrome (SIRS) are associated with an increased risk of impaired development in premature children (4-6). Objective of the study is to elucidate the risk of neurodevelopmental outcomes in children that had neonatal sepsis, according to the birth weight and also interpretation the pathologies that have disturbed harmonious development during first year of life. Material and methods: Retrospective study of records of 207 preterm children weighing between 500-2500 g who have suffered intrauterine infection during the neonatal period and were taken in Follow-up by the Centre for diagnosis and surveillance of neonatal PMSI Scientific Research Institute in the Field of Mother and Child care during 2009. Results: Results: By the age of 1 year in group of premature babies with birth weight less than 1500g at high environmental risk ratio the corrected age is virtually 1:1, at this age there was no case of low risk. Conclusions: From wide range of neorodevelopmental disorders of the very low birth weight and low birth weight babies with generalized infection were determined: disorders of muscle tone, hydrocephalus and/or secondary ventriculomegaly, cerebral congenital malformations, cerebral palsy, neurosensory deficiencies (retinopathy of prematurity, microphthalmia, optic nerve atrophy) and behavioral disorders such as attention deficit hyperactivity disorder syndrome (ADHD) that still represent the need of continuous rehabilitation.