This article highlights the changes in life expectancy in Moldova under the influence of the COVID-19 pandemic. The results show a decrease in life expectancy in 2020, compared to 2019, by 0.9 years in males and 1.3 years in females. The increase in mortality has been particularly pronounced in the ages above 55 and 40 for males and females, respectively. The observed rise in the number of deaths occurred as a result of joint factors, such as the increasing number of persons diagnosed with COVID-19, postponement of planned treatments for the patients with chronic diseases, overloading of the medical system during the pandemic, etc. During the period of self-isolation and a decrease in economic activities, a decrease in mortality caused by external factors could be observed, which contributed to the increase in the life expectancy components among the young population.