Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
232 0 |
SM ISO690:2012 SCHWARZ, Norbert G., BERNARD, Helen, MELNIC, Anatolie, BUCOV, Victoria, CATERINCIUC, Natalia, AN DER HEIDEN, Matthias, ANDREWS , Nick J., PEBODY, Richard G., AIDYRALIEVA, Chinara, HAHNE, Susan J.M.. Mumps outbreak in the Republic of Moldova, 2007-2008. In: Pediatric Infectious Disease Journal, 2010, nr. 8(29), pp. 703-706. ISSN 0891-3668. DOI: https://doi.org/10.1097/INF.0b013e3181d743df |
EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
Pediatric Infectious Disease Journal | |
Numărul 8(29) / 2010 / ISSN 0891-3668 /ISSNe 1532-0987 | |
|
|
DOI:https://doi.org/10.1097/INF.0b013e3181d743df | |
Pag. 703-706 | |
Rezumat | |
Background: Moldova experienced a nationwide mumps outbreak between 2007 and 2008. Single-dose monovalent mumps vaccination at 15 to 18 months was introduced in 1983, replaced by a 2-dose MMR schedule at age 1 and 6 to 7 years in 2002. We investigated the outbreak to quantify its extent, explore the role of primary and secondary vaccine failure, and provide control recommendations. Methods: We analyzed national mumps surveillance and vaccination coverage data to estimate vaccine effectiveness (VE) using the screening method. A retrospective cohort study in 5 educational institutions was conducted to determine age-specific attack rates (ARs) and VE. We compared vaccine strain-specific ARs. Isolation and genotyping of mumps virus strains were performed. Results: Of 31,142 cases reported during October 2007 and July 2008, 80% were in 15-to 24-year-olds. Of cases with information (66%), 92% were vaccinated once, 4% twice. One-dose mumps VE estimates based on surveillance data over 1997-2001 declined from 91% (95% CI: 88%-92%) in 2-year-olds to 72% (70%-74%) in 15-to 19-year-olds. In the cohort study (n = 1589), VE was-40% (-120% to 20%) for 1 dose. For 2 doses it was 62% (-43% to 90%) in 13-to 15-year-olds. ARs were higher in individuals vaccinated with Urabe strains (43%) than with Leningrad-Zagreb strains (14%, P < 0.001). Mumps virus genotype G5 was identified. Conclusions: Low effectiveness of single-dose mumps vaccination was the main cause of the outbreak. Waning immunity may have contributed to this. The risk of mumps in 2-dose vaccinees was low. Other countries in which large population groups have received <2 doses of mumps vaccine may face similar outbreaks. |
|
Cuvinte-cheie disease outbreak, measles-mumps-rubella vaccine, mumps, mumps vaccine, vaccine effectiveness, vaccine failure |
|
|