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SM ISO690:2012 SÂRBU, Zinaida, OSTROFEŢ, Constantin. Menstrual disorders in young patients with metabolic syndrome Menstrual disorders in young patients with metabolic syndrome. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 400. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Rezumat | ||||||
Background. According to WHO data, metabolic syndrome (MS) has a negative social and economic impact, as it ranks first in the structure of risks of developing cardiovascular, thromboembolic and reproductive pathology. The incidence of MS is 23.7%, and the impact of menstrual dysfunctions on MS is unknown. Objective of the study. Evaluation of the type of menstrual disorders in young women with MS. Material and methods. Clinical: height, weight, BMI; abdominal circumference, BP; hormonal profile: FSH, LH, TSH, Prl, E1, E2, total T, free T, DHEAS; US exam. Results. It was found that the initially reduced level of E2 and increased E1 in blood plasma in this category of patients causes the increased secretion of GnRH, which, in its turn, increases the sensitivity of receptors to gonadotropic pituitary cells. As a result of the increased production of LH by adenohypophysis increases disrupting the ratio of LH / FSH more than 1, followed by hypersecretion of androgens by the ovarian cells with their subsequent hypertrophy.The relative decrease of FSH level leads to a decrease of aromatases secretion, converting androgens to estrogens and a secondary decrease in the level of E2 and anovulation. There is a pathological vicious circle. Conclusion. There is an increased level of E in blood plasma in this category. Clinically, it is assessed by hypomenstrual syndrome, infertility and aggravation of MS severity. |
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Cuvinte-cheie metabolic syndrome, menstrual disorders, obesity, dyslipidemy, sindrom metabolic, dereglări menstruale, obezitate, dislipidemie |
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