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Articolul urmator |
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SM ISO690:2012 RODOMAN, Iulia, PÎRŢU, Lucia, DORIF, Alexandr, SAKARA, Viktoria K., PALII, Ina. Subclinical left ventricular dysfunction in children with duchenne muscular Dystrophy. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 361. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Pag. 361-361 | ||||||
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Background. The prognosis for DMD is strongly associated with cardiac dysfunction, mainly represented by dilated cardiomyopathy, which usually occurs in the second decade. However, clinical detection can be challenging because of the lack of classical heart failure symptoms due to wheelchair dependence. Objective of the study. to assess echocardiographic measurements for early identification and discovery of myocardial dysfunction in pediatric patients with DMD using Speckle tracking analyze Material and Methods. Ten patients with DMD, aged 3–15 years, diagnosed with DMD, were enrolled in the study. The patients have been follow up-ed by assessing biochemical and instrumental methods. Results. None of the patients had symptoms or a history of cardiac involvement. Baseline measurements: mean age was 8.6 ± 4.08, heart rate - 95 ± 13 /min, ejection fraction Teicholz 55.7 ± 6.12 %. Global longitudinal strain from the combined apical four-, three- and two-chamber views was significantly lower: − 14.9 ± 3.5%. LV areas showing reduction of strain were mostly belonged to the basal inferior segments (n = 5) in patients with DMD. Conclusion. Speckle-tracking echocardiographic imaging is rising as a noninvasive functional useful biomarker to recognize in DMD-cardiomyopathy detection, by assessing early cardiac dysfunction and consequently start medical therapy at an earlier stage of the disease |
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Cuvinte-cheie Duchenne, speckle tracking, GLS, Duchenne, speckle tracking, SLG |
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