In field experience, the influence of two-fold processing of table grape plants was studied by the Gibber-ellin, Zircon and Epin extra growth regulators on the structure of the bunch, yield and saccharinity of berry juice depending on the hydrothermal conditions of the growing season. It was established that the treatment of grape plants of the Great variety by growth regulators allows to reduce the negative influence of adverse ex-ternal factors and increase the productivity and quality of grape berries. Under more humidified conditions, treatment of Epin Extra plants (3.2 ml/l) contributes to an increase in yield by 82%, in dry conditions - Zir-conom (0.6 ml/l) by 1.5 times compared to control. The use of growth regulators contributes to a greater ac-cumulation of sugar in the juice of berries.