Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
324 3 |
Ultima descărcare din IBN: 2024-05-09 17:02 |
Căutarea după subiecte similare conform CZU |
618.31-006.882.04:575.117 (1) |
Mедицинские науки (11480) |
Общая генетика. Общая цитогенетика. Иммуногенетика. Эволюционное учение. Видообразование. Филогенез (432) |
SM ISO690:2012 DAVID, Valeriu, PETROVICH, Virgil, ŞAPTEFRAŢI, Lilian, CARPENCO, Ecaterina, FRANȚ, Elena. Evaluation of p57 expression in early term disturbed pregnancies with molar vs non-molar status. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 18. ISSN 2345-1467. |
EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
|
||||||
CZU: 618.31-006.882.04:575.117 | ||||||
Pag. 18-18 | ||||||
|
||||||
Descarcă PDF | ||||||
Rezumat | ||||||
Background. The molar and non-molar lesions in the germinal compartment are determined during histomorphological examination and treated as inconclusive. The establishing of a marker by immunohistochemical investigations could influence the accuracy of the morphopathological diagnosis. Objective of the study. Differentiated evaluation of p57 immunoexpression in the trophoblastic germ compartment in compromised pregnancies with molar vs non-molar profile. Material and methods. Abortion products from 15 patients diagnosed with hydatidiform mole by ultrasound imaging and morphology. Control group: pregnancies solved on social indications (n = 18) and shortterm disordered pregnancies (n = 16). Immunohistochemical evaluation included the anti-p57 marker (NCL-L-p57, clone 25B2, dilution: 1:100, detection system: NovolinkTM MaxPolymer (RE7280-K, Leica). Results. The hydatidiform mole was classified according to the differentiated anti-p57 immunoexpression in the villous trophoblast into: MHC - 8 cases (53.35%) in case of negative immunoexpression or expression in ˂10% of villous cytotrophoblast and MHP - 7 cases (46.6 %) in case of positive expression in ˃10% of the villous cytotrophoblast. Basal deciduous and extravillous cytotrophoblast served as internal control and were positive in 100% cases. Negative control - lack of immunoexpression in hepatocytes. In the control group, the positive immunoexpression was attested in >10% of cases in the villous trophoblast. Conclusions. Differentiated immunoexpression of p57 protein in the cytotrophoblastic germ compartment allows the sub-classification of the molar pathology into complete vs partial form in the absence of differentiation between MHP and non-molar lesions. |
||||||
Cuvinte-cheie anti-p57, fetal concept, hydatidiform mole, trophoblastic disease, anti-p57, concept fetal, mola hidatiformă, boală trofoblastică |
||||||
|