The material was the data on the endemic fish U.krameri parasites sampled in the Lower Dniester wetlands neighboring drainages and the Danube Delta in 2000-2018. A total of 137 fish specimens (89 and 48, respectively) were fully parasitologically dissected. In the surveyed U.krameri individuals nearly 120 species taxa of the parasites belonging to different systematic groups were revealed: 45 Ciliophora, 21 Plathelminthes, 16 Euglenozoa, 8 Sporozoea & Nemathelminthes, 7 Cnidaria, 3 Arthropoda, 2 Acanthocephales, Annelida & Mollusca, 1 Metamonada, Amoebozoa, Microsporidia, Oomycota & Chytridiomycota. Obtained data demonstrated that diversity of parasites of the Lower Dniester U.krameri populations is much richer and is distinguished by originality, compared with those of the Danube basin: although the U.krameri populations from the Dniester have a rich community of parasites, some „Dniester species” are absent or very rare; almost all identified species present a novelty for this fish-host and 12 of them were described as previously unknown; the parasite fauna of the examined U.krameri includes 18 host-specific species, one species common with U.limi and 12 species common with relative Esox lucius. The total extensity of invasion of fishes was 100%; however, the extensity of invasion with certain species of parasites was insignificant. The maximum number of parasites species for one fish reached 18, and usually 48. Males are slightly more infested than females. By prevalence, species diversity and by numerical abundance in almost all the biotopes species/combinations of protists (ectobiont ciliates, blood flagellates, sporozoans) and worms (trematodes, nematodes) were dominant. Among the body parts of the sampled fishes, the gills, skin and gut had the highest parasitic load. The parasitological situation of U. krameria populations inhabiting the Lower Dniester is unfavorable and tense. More than a third of the founded parasites species may be considered pathogenic for the ichthyocenosis. The prevalence rate of U. krameri parasites is alarming, it is difficult to assume that such high values of infestation did not cause severe damage and even mortalities among fish. The carriage of many pathogenic parasites by this fish, under certain circumstances, may pose a potential threat to the survival of its unique populations of the Dniester. The composition of the parasites community of the U.krameri in the lower Dniester biotopes was similar in most cases in its structure, but extensity/intensity of invasion was variable and depended on the peculiarities of the biotopes. Meanwhile, it should be noted that lower species diversity of the parasites and lower intensities of invasion of U.krameri populations in restored and newly created hydrobiotopes of the Dniester delta were discovered, comparatively with long-standing biotopes. The structural rearrangement in the parasitic fauna of the U.krameri from new biotopes is manifested in a decrease in the species richness due to the disappearance of typical parasites for hypertrophic biotopes. The peculiarities of the diversity and abundance of parasites in the U.krameri adequately reflect the ecological state of the biotopes, their hydrobiocenosis, as well as the impact of the waterthe hydrologic regime, i.d. the intensity of hydropower plants water discharges. Acknowledgement: Current work was realized in the frame of the Joint Operational Black Sea Programme 2014-2020, the Project BSB 165 „HydroEcoNex”, with the financial assistance of the European Union.