Multiple Sclerosis (MS) is a demyelinating autoimmune disease impairing diverse functional systems controlled by the brain and spinal cord. Impairment of mobility and as a result decline of walkability is one of the conseqences of disease progression thus reducing enormously patients autonomy and quality of daily life. Rehabilitation in a multidisciplinary team remains the best option to maintain physical activity and walking over the course of disease. The optimal duration of inpatient rehabilitation has not been investigated evidence based. The usual inpatient course that is offered by insurances does not exceed 3 weeks. Our study has shown a significant improvement of walkability in MS-patients beyond 4 weeks of intensive inpatient rehabilitation. With a view to maintaining the autonomy in mobility of MS-patients and hence to improve their quality of life there is a need for prolonged inpatient rehabilitation program exceeding 3 weeks of a standard duration course. The optimal terms of rehabilitation have to be determined individually and the results have to be evaluated in further studies.