We conducted this study to evaluate the neuropharmacological effects of agatisflavone (1, 3 and 5 μg / l) on neurocognitive performance, as well as the possibility of improving memory and preventive against the onset of Alzheimer's disease pathology. In this study we used an animal model of dementia induced by the administration of scopolamine (100μm / l). In the Y-maze test, one-way ANOVA revealed a significant effect of treatment on the percentage of spontaneous alternation. Animals treated with scopolamine (100 µM) showed a significant decrease in the percentage of spontaneous alternation compared to the control group (p <0.0001). In contrast, fish treated with scopolamine and subjected to with agatisflavone treatment (3 μg / l and 5 μg / l) showed a significant increase in the percentage of spontaneous alternation (p <0.01 for 3 μg / l and p <0.001 for 5 μg / l) at a level close to the effect of donepezil. Our findings suggest that administration of agatisflavone can restore memory degradation and induce neuroprotective effects in dementia animals. Therefore, agatisflavone could be used to improve the memory degradation associated with dementia.