The paper presents the preliminary results of five years’ multidisciplinary researches (2010–2014 years) of the new Lower Palaeolithic Bayraki site, situated in the vicinity of Dubossary town in Moldavia, on the high terrace (VII) of the Dniester River. In the Lower and Middle Pleistocene deposits are discovered six layers including lithic artefacts of Lower Palaeolithic character. Two layers (I and II) relate to deposits dated by the Brunhes period and four layers (III, IV, V and VI) are attributed to the Matuyama period. The highest number of artefacts (884 objects) is issue from the layer V (the Jaramillo period), whose lithic industry has an Oldowan character. In other layers are found few flint archaeological objects and sporadic fragments of indeterminable bones. In the layer III is found a fossil horse mandibular (Equus sussenbornensis). At present, this site presents the oldest Low Pleistocene across all East European Plain.