Bisphosphonates are used worldwide as one of the standard treatments for osteoporosis [1] as they bind to hydroxyapatite crystals inhibiting crystal breakdown and suppressing bone resorption [2]. Bisphosphonates used as inhibitors of bone resorption all contain two phosphonate groups attached to a single carbon atom, to give a ‘P–C–P’ structure. The bisphosphonates are therefore stable analogues of naturally occurring pyrophosphate compounds, which now helps to explain their intracellular as well as their extracellular modes of action [3]. Amongst this new generation of compounds that were synthesized to optimize their antiresorptive effects, the most potent antiresorptive bisphosphonates were those containing a nitrogen atom within a heterocyclic ring as in risedronate and zoledronate [3]. The thermally induced interactions of risedronate (Fig.1) in 1:1 mass ratio binary mixture with talc, silica, magnesium stearate, microcrystalline cellulose, starch and mannitol (Fig.2) were studied under non-isothermal conditions. As kinetic methods, integral methods (Flynn–Wall–Ozawa) and one differential method (Friedman) were used. This analysis was completed by using the nonparametric kinetics method (NPK). Keywords: risedronate-excipients mixture, thermally induced interactions, kinetic study. Fig.1. TG/DTG/HF curves for risedronate in air with heating rate 10 ℃/min Fig.2 TG/DTG/HF curves for risedronate: mannitol 1:1 in air with heating rate 10 ℃/min