Artemether and artesunate, structural derivatives of artemisinin, possess a sesquiterpenic structure with an endoperoxidic bond that has been shown to determine antitumor and antiproliferative properties, being of great importance in the oncological research field [1]. a b Chemical structure and thermoanalytical curves TG/DTG/HF for artemether (a) and artesunate (b) This study presents the comparative analysis regarding the thermal degradation process (including kinetic study) in dynamic air atmosphere, for two similar-structured compounds: artemether and artesunate. As kinetic methods, two integral methods (Kissinger–Akahira–Sunose and Flynn–Wall–Ozawa) and one differential method (Friedman) were used. This analysis was completed by using the nonparametric kinetics method (NPK) in order to differentiate the physical and chemical processes that accompany the thermal degradation process [2, 3].